Linked Life Data

7172973

Source:http://linkedlifedata.com/resource/pubmed/id/7172973

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1983-2-14
pubmed:abstractText
The influence of plasma protein binding on the maternofetal transfer of diazepam was studied in the perfused human placental lobule. Substitution of buffered salt perfusate in both maternal and fetal circuits for a perfusate with plasma proteins did not alter diazepam transfer significantly. Diazepam placental uptake was shown to be important in perfusion, with both types of perfusates. Comparison with the less liposoluble and less protein-bound benzodiazepine, fosazepam, revealed a marked difference in placental uptake but not in maternofetal transfer. In incubation studies, the kinetics of placental uptake confirmed this difference.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-8305
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Maternofetal transfer of two benzodiazepines. Effect of plasma protein binding and placental uptake.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't