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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-2-14
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pubmed:abstractText |
The hypothalamo-extrahypophyseal neurophysin pathways (HEH) and the three hypothalamic nuclei secreting neurophysins, the supraoptic (SON), paraventricular (PVN) and suprachiasmatic (SCN) nuclei, of normal and hypophysectomized rats were studied by application of the immunoperoxidase procedure. Eight well-defined HEH pathways were recognized. Their main sites of projection were: lateral septum and subfornical organ (1 and 2); tractus diagonalis (3); medial nucleus of the amygdala and lateral ventricle (4); nucleus periventricularis thalami, nucleus habenulae lateralis and periaqueductal gray (5); periaqueductal gray, pineal organ, collicular recess and subependymal region of the fourth ventral (6); dorsomedial nucleus and premammillary area (7); perimammillary region, corpus trapezoideum, ventral surface of medulla oblongata, nucleus tractus solitarii, nucleus commissuralis, substantia gelatinosa and formatio reticularis lateralis of the medulla oblongata and spinal cord (8). Neurophysin fibers of unknown origin were found in the frontal cerebral cortex. It was noted that in pathway 5 the amount of immunostainable material undergoes changes with age. The three neurophysin-secreting nuclei reacted differently following hypophysectomy. Among the HEH pathways the only one that seemed to be affected by hypophysectomy was that innervating the lateral septum. It is suggested that the neurons that survive hypophysectomy either do not project to the neural lobe or, alternatively, display axon collaterals projecting outside the neural lobe. Such a neuronal population could be the origin of the HEH pathways.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0302-766X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
227
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-112
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7172216-Aging,
pubmed-meshheading:7172216-Animals,
pubmed-meshheading:7172216-Brain,
pubmed-meshheading:7172216-Brain Stem,
pubmed-meshheading:7172216-Cerebral Cortex,
pubmed-meshheading:7172216-Female,
pubmed-meshheading:7172216-Hypophysectomy,
pubmed-meshheading:7172216-Hypothalamus,
pubmed-meshheading:7172216-Male,
pubmed-meshheading:7172216-Neural Pathways,
pubmed-meshheading:7172216-Neurophysins,
pubmed-meshheading:7172216-Neurosecretory Systems,
pubmed-meshheading:7172216-Paraventricular Hypothalamic Nucleus,
pubmed-meshheading:7172216-Pineal Gland,
pubmed-meshheading:7172216-Rats,
pubmed-meshheading:7172216-Suprachiasmatic Nucleus,
pubmed-meshheading:7172216-Supraoptic Nucleus
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pubmed:year |
1982
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pubmed:articleTitle |
Neurophysin pathways in the normal and hypophysectomized rat.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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