Linked Life Data

717175

Source:http://linkedlifedata.com/resource/pubmed/id/717175

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1979-1-15
pubmed:abstractText
Studies on the basis of differential responsiveness of H-2b mice to gallinaceous lysozymes suggest T cell involvement and active T cell suppression with those lysozymes not responded to. Results from other laboratories suggesting a directive role for macrophages through limited presentation are summarized. A model is presented proposing that suppressors (recognizing a determinant only on lysozymes not responded to) are present in all strains; that suppression requires antigen bridging between suppressor determinant and positive T determinant; that this bridge is disrupted in all strains but H-2b; and that this failure to disrupt the antigen bridge is a result of a genetically (Ia) controlled loss of a normal macrophage processing step.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
A model implicating altered macrophage function in H-2 linked nonresponsiveness to hen lysozyme.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.