Linked Life Data

7168539

Source:http://linkedlifedata.com/resource/pubmed/id/7168539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-5-27
pubmed:abstractText
The metabolism of febantel has been investigated in the rat and the sheep. The general pathway seems to be similar in both species: ten urinary metabolites are the result of cyclisation, oxidation and/or hydrolysis process. Using synthetic samples, the embryotoxic study of all individual metabolites has been performed in the rat. Unchanged febantel and two other metabolites are responsible for teratogenic effects. A four steps toxogenic pathway is described which finally leads to the ultimate known teratogen: methyl (5-(phenylsulfinyl)-1H-benzimidazole-2-yl) carbamate. Metabolic similarities with other anthelmintics and residual consequences are discussed.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-4193
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-70
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Metabolism-embryotoxicity relationship of febantel in the rat and the sheep].
pubmed:publicationType
Journal Article, English Abstract