Linked Life Data

7168347

Source:http://linkedlifedata.com/resource/pubmed/id/7168347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-5-27
pubmed:abstractText
Ni-induced coronary vasoconstriction has been studied in the dog heart in situ in the presence of the selective Ca-antagonist verapamil, and after blocking the alpha-receptors with phenoxybenzamine (PBZ). Verapamil totally abolished the coronary blood flow (CBF) and basal conductance (BC) decreasing effect of low doses of Ni2+ (0.02-0.2 mg/kg-1). The effect of higher doses of Ni2+ (2.0-20.0 mg/kg-1) was reversed by verapamil, i.e. high doses of exogenous NiCl2 increased CBF and BC in the presence of verapamil. The CBF decreasing effect of nickel was not significantly influenced by PBZ pretreatment. The results indicate that trace amounts of exogenous NiCl2 induce coronary vasoconstriction in the dog heart in situ by enhancing Ca2+-influx into vascular smooth muscle cells, which is not mediated by alpha-receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6756
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-90
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of verapamil and phenoxybenzamine on nickel-induced coronary vasoconstriction in the anaesthetized dog.
pubmed:publicationType
Journal Article