Linked Life Data

7167768

Source:http://linkedlifedata.com/resource/pubmed/id/7167768

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
1983-5-27
pubmed:abstractText
The human amnion membrane consisting of a single layer of epithelium attached to the continuous basement membrane and the underlying collagenous stroma has been used to study tumor invasion in vitro by means of electron microscopy. Three cell lines utilized in these experiments were established from surgical specimens of human squamous cell carcinomas of the tongue and larynx. The cultivation of amnion membrane for 48h or longer leads to some alterations in the morphological appearance. All three carcinomas form aggregates which appear firmly attached to the amnion epithelium and are able to establish contacts to the basement membrane within 96h. In two cases the basement membrane reveals local defects and some cells have extended processes into the collagenous tissue. However, none of the tumor cells of the three carcinomas have broken through the basement membrane and grown into the collagenous stroma. Some differences of interaction between amnion epithelial cells and tumor cells of the three carcinomas are apparent. These ultrastructural findings show, that the amnion membrane model allows morphological analysis of various steps of tumor invasion under standardized conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0586-5581
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
741-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Interactions of tumor cells with human amnion membrane: a model for studying tumor invasion in vitro.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't