Linked Life Data

7165861

Source:http://linkedlifedata.com/resource/pubmed/id/7165861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1983-5-5
pubmed:abstractText
In the CA1 area of the hippocampus of urethane-anaesthetized rats, the greatest delta[K+]omicron and delta[Ca2+]omicron evoked by repetitive fimbrial-commissural stimulation were always found in the pyramidal cell layer; but there were large increases in [K+]omicron over a wide range of depth, whereas a major fall in [Ca2+]omicron was localized almost exclusively to the level of the pyramidal layer. A sustained focal negative potential was also evoked by fimbrial stimulation; it resembled delta[K+]omicron in time course and depth distribution and therefore probably reflected cellular depolarization caused by increased [K+]omicron. The close correlation between delta[Ca2+]omicron and delta[K+]omicron and the appearance of population spikes (especially in bursts of three to four spikes) indicate that pyramidal cell firing and corresponding K-outward and Ca-inward currents are mainly responsible for the accumulation of K+omicron and the depletion of Ca2+omicron. In CA3 pyramidal areas, delta [K+]omicron and delta[Ca2+]omicron were comparable in magnitude and distribution to changes seen in CA1, but they occurred after a longer latency, and the major delta[Ca2+]omicron had a longer duration, consistent with a more prolonged Ca2+ current.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0008-4212
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1658-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Depth distribution and mechanism of changes in extracellular K+ and Ca2+ concentrations in the hippocampus.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't