Linked Life Data

7162344

Source:http://linkedlifedata.com/resource/pubmed/id/7162344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20-21
pubmed:dateCreated
1983-4-21
pubmed:abstractText
Phosphorylation of proteins in synaptic membranes of rat striatum by endogenous kinases was quantified by scanning the optical density on radioautograms made from gels after electrophoresis of assay samples. Neither the decreased phosphorylation found in samples from morphine-tolerant rats could be raised to control levels, nor could samples from untreated rats be raised to those found after acute opioid administration by the addition of Ca++ and calmodulin to the assay. However, the addition of opioids in vitro to the assay was able to inhibit the stimulation of protein kinase activity by Ca++ and calmodulin. Calmodulin seemed to be transported from membranes to cytosol of striatal synaptosomes from morphine tolerant rats. This phenomenon has been related to striatal dopamine receptor supersensitivity (5, 10), a condition suggested by many kinds of evidence in tolerant animals. After acute administration of etorphine or methionine-enkephalin, the levels of calmodulin were increased in both compartments of striatal synaptosomes. The increased membranal levels may be related to its ease of extraction from the membranes and thus to a physical change in calmodulin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2283-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
The effect of opioids on striatal calmodulin levels.
pubmed:publicationType
Journal Article