Linked Life Data

7161699

Source:http://linkedlifedata.com/resource/pubmed/id/7161699

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-4-15
pubmed:abstractText
The metabolism and bioavailability of 14C clometacin was studied in the rat. The drug is rapidly excreted in the urine and in the feces. It is not detected in any tissues of the treated animals 48 hours after administration. The metabolism of clometacin is very limited under the experimental conditions used in our study. More than 85% of the drug is excreted in an unchanged from. One metabolite, representing 4 to 10% of the excreted radioactivity, was found in the urine and identified as 1-(2-methyl-3-p-chloro phenylcarbinol-6-hydroxy) indol acetic acid. This metabolite was not detected in the feces, nor in the different tissues 4 or 48 hours after i.v. or oral administration of the drug.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0047-2166
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Clometacin--1. Metabolism and bioavailability of clometacin and its metabolites in the rat].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't