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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1983-4-7
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pubmed:abstractText |
Meiotic maturation of amphibian oocytes induced by progesterone is known to be regulated by protein phosphorylation. To investigate a possible role for protein phosphatase-1 in this process, the effect of phosphatase inhibitor-2 was determined on the in vivo rate of dephosphorylation of phosphorylase a and on the rate of oocyte maturation. Dephosphorylation of microinjected phosphorylase a was inhibited up to 40% in the presence of inhibitor-2, with half-maximal inhibition at an intracellular concentration of 0.6 microM. Inhibitor-2 also caused over a 3-fold increase in the half-time for maturation, suggesting a possible role for protein phosphatase-1 in the regulation of meiosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7160468-Animals,
pubmed-meshheading:7160468-Dose-Response Relationship, Drug,
pubmed-meshheading:7160468-Enzyme Inhibitors,
pubmed-meshheading:7160468-Female,
pubmed-meshheading:7160468-Manganese,
pubmed-meshheading:7160468-Oocytes,
pubmed-meshheading:7160468-Ovum,
pubmed-meshheading:7160468-Phosphorylase a,
pubmed-meshheading:7160468-Proteins,
pubmed-meshheading:7160468-Xenopus laevis
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pubmed:year |
1982
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pubmed:articleTitle |
In vivo actions of protein phosphatase inhibitor-2 in Xenopus oocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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