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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1983-4-7
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pubmed:abstractText |
The ability of normorphine to inhibit the muscular twitches elicited by electrical stimulation of the longitudinal muscle of the guinea-pig ileum was antagonized by 4-aminopyridine (4-AP). Incubation with 4-aminopyridine (4-AP) caused a marked increase of the normorphine IC50 and this effect was not modified by naloxone or by the Ca2+ channel blocker, verapamil. Although verapamil caused a significant decrease of the normorphine IC50 it also caused a potent reduction of the contractile effect of acetylcholine. The results suggest that 4-AP and verapamil act on different Ca2+ pools and that verapamil does not primarily affect the presynaptic Ca2+ pool involved in opiate action.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7160427-4-Aminopyridine,
pubmed-meshheading:7160427-Acetylcholine,
pubmed-meshheading:7160427-Aminopyridines,
pubmed-meshheading:7160427-Animals,
pubmed-meshheading:7160427-Calcium,
pubmed-meshheading:7160427-Drug Interactions,
pubmed-meshheading:7160427-Guinea Pigs,
pubmed-meshheading:7160427-Ileum,
pubmed-meshheading:7160427-Male,
pubmed-meshheading:7160427-Morphine Derivatives,
pubmed-meshheading:7160427-Muscle, Smooth,
pubmed-meshheading:7160427-Muscle Contraction,
pubmed-meshheading:7160427-Verapamil
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pubmed:year |
1982
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pubmed:articleTitle |
Effect of 4-aminopyridine and verapamil on the inhibitory action of normorphine on the guinea-pig ileum.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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