Linked Life Data

7157775

Source:http://linkedlifedata.com/resource/pubmed/id/7157775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-3-17
pubmed:abstractText
The capacity of two gangliosides, GD1a and GT1b isolated from bovine brain to function as specific receptors of influenza virus was determined. A primary chick fibroblast culture was treated with neuraminidase to destroy natural receptors, the cells were loaded with gangliosides GD1a and GT1b, inoculated with 3H-uridine-labeled virus, and virus adsorption and penetration into the cell nucleus were determined. Both gangliosides were shown to restore virus adsorption to the cell surface and penetration of viral structures into the cell, GT1b facilitating more effective transportation of viral structures into the nuclei than GD1a and inducing penetration into the nuclei nearly 1.5-fold as much amount of viral structures as in native cells. The same ganglioside partially restored virus-induced hemolysis upon loading it on erythrocytes pre-treated with neuraminidase. It is concluded that ganglioside GT1b is a specific receptor for influenza virus. 3.9% of this ganglioside was found in chick fibroblast lipids.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0507-4088
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
661-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Gangliosides--specific receptors for the influenza virus].
pubmed:publicationType
Journal Article, English Abstract