Linked Life Data

7156876

Source:http://linkedlifedata.com/resource/pubmed/id/7156876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-3-11
pubmed:abstractText
The effect of cholinergic, alpha-adrenergic, and beta-adrenergic blockade on human pancreatic polypeptide (HPP) release has been tested in six normal subjects before and after a meal. The response to food was abolished by atropine and significantly enhanced by phentolamine and propranolol. The increase induced by phentolamine occurred during the primary phase 0-60 min after food, and that caused by propranolol was observed during the secondary phase 60-120 min postprandially. A radioimmunoassay for HPP, evaluated by accepted criteria of reliability, is described. Various fractions of the 125I-BPP tracer peak have been evaluated. Those of the central portion proved to be superior to the others because of the constant immunoreactivity and the constant incubation damage during the observation period. Serum and plasma samples were subject to different conditions of preservation before analysis of HPP. It is concluded that preservation with aprotinin heparin, collection in chilled tubes, or instant centrifugation and freezing does not improve the stability of HPP after sampling. The present study confirms a positive correlation between age and fasting HPP concentrations (R = 0.15, p = 0.05), but no difference in HPP levels between men and women has been demonstrated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0036-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
801-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of cholinergic and adrenergic blockade on human pancreatic polypeptide secretion in healthy subjects.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't