Linked Life Data

7156818

Source:http://linkedlifedata.com/resource/pubmed/id/7156818

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-3-11
pubmed:abstractText
During the last decade an increased incidence of the adverse reactions to drugs with liver involvement was found. The liver lesions produced by drugs constituted a constant concern. We followed the course of liver disease produced by tuberculostatics, cytostatics, antidepressive, antibiotics, narcotics, antirheumatics, by biochemical, immunological and morphological investigations (needle biopsy of the liver with optical and electronic microscopy). The pattern of the damage to the liver ranges from minimal functional changes to severe aspects with cytolysis and cholestasis. Hypersensitivity to drugs (cutaneous eruption, rash, fever, eosinophilia) were observed only in three cases. The cholestatic clinical form was the most frequently encountered, raising problems of differential diagnosis with acute viral hepatitis and obstructive jaundice. Clinical evolution of drug induced hepatic lesions is favourable as soon as the administration of drug is arrested. Chronic evolution, as reported in the literature when the administration of hepatotoxic drug is continued, was noted only in one patient who was using Chlorpromazine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0377-1202
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:articleTitle
Drug induced hepatitis.
pubmed:publicationType
Journal Article