Linked Life Data

7154669

Source:http://linkedlifedata.com/resource/pubmed/id/7154669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-3-17
pubmed:abstractText
1. In order to confirm the potential anti-anaphylactic properties of verapamil, the effects of this calcium antagonist were assessed on several experimental models: anaphylactic shock in mice, passive cutaneous anaphylaxis in Rats, and degranulation of Rat peritoneal mast cells. 2. At a dose of 5 mg/kg IP, half-an-hour before challenge, verapamil decreased systemic anaphylaxis-induced lethality significantly. On the reverse, in the same conditions, it was unable to inhibit passive cutaneous anaphylaxis at 0.1-0.5-1 or 10 mg/kg; it did even increase it at a dose of 5 mg/kg IP over the last 3 days. However, specific degranulation of rat peritoneal mast cells was significantly decreased after in vitro incubation with verapamil (0.25 and 1.25 micrograms/ml or after pretreatment with 5 mg/kg/day over 3 days). 3. These early results confirm the hypothesis of verapamil anti-anaphylactic properties whose consequences warrant further investigation.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-793X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
573-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Anti-anaphylactic properties of verapamil. First experimental assessment].
pubmed:publicationType
Journal Article, English Abstract