Linked Life Data

7152456

Source:http://linkedlifedata.com/resource/pubmed/id/7152456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-3-17
pubmed:abstractText
Rats with a total portacaval anastomosis (PCA, PC-SS) develop preneoplastic and neoplastic lesions in the urinary tract. In contrast to this, animals with a modified shunt (mPCA) do not develop these lesions. To evaluate the possible role of bile acids excreted with the urine for tumor development, total plasma bile acid concentration and 24 hours urinary bile acid excretion were measured radioimmunologically in rats with total and modified shunts. Additionally the renal 14C-glycocholic acid excretion into the urine was studied after oral administration. Total plasma BA increased from 4.89 +/- 1.0 mumol/l in sham-operated controls to 77.7 +/- 39 mumol/h in PCA and 52.9 +/- 36.7 mumol/l in mPCA rats (p less than 0.001 vs controls, PCA vs mPCA = n.s.). Urinary bile acid excretion rose from 0.2 +/- 0.29 mumol/24 hours in controls to 4.47 +/- 4.49 in PCA and 2.55 +/- 2.22 mumol/24 hours in mPCA rats (p less than 0.001 vs control; PCA vs mPCA = n.s.) 14C-glycocholic acid was excreted within 24 hours into the urine in 13.6 +/- 11.5% in PCA and 26.3 +/- 23.5% of the administered dose in mPCA-rats (controls; 2.98 +/- 0.67%, p less than 0.001; PCA vs mPCA = n.s.). Since renal BA-excretion is similar in both shunted groups, urinary BA does not seem to be of primary significance for cancer development in the urinary tract of totally shunted rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0172-6390
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
232-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Renal bile acid excretion as a cause of neoplastic lesions in the urinary tract after total portacaval shunt in the normal rat?
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't