Linked Life Data

7151886

Source:http://linkedlifedata.com/resource/pubmed/id/7151886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-3-24
pubmed:abstractText
Cynomolgus monkeys with surgically untouched, aniridic, or ciliary muscle disinserted eyes underwent two-level constant pressure perfusion of the anterior chamber to determine total outflow facility before and after intracameral infusion of bradykinin triacetate (0.1, 1, 10 micrograms), histamine dihydrochloride (1, 10, 100 micrograms), or serotonin creatinine sulfate (1, 10, 100 micrograms). Bradykinin had no effect on facility in non-disinserted eyes, but significantly decreased facility in disinserted eyes at all three dosages. Histamine tended to decrease facility in non-disinserted and disinserted eyes at all three dosages, although the decrease was not consistently significant statistically. Serotonin tended to decrease facility in non-disinserted eyes at dosages of 10 and 100 micrograms, although the effects were not statistically significant; 1 microgram had no effect. In disinserted eyes, 1 microgram significantly decreased facility, while the higher dosages had no (10 micrograms) or less (100 micrograms) effect. No simple mathematical/physiological description of the drug-induced facility decreases could be formulated. The facility decreases could be due to drug effects directly on the outflow pathways or secondary to blood-aqueous barrier breakdown.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of serotonin, histamine and bradykinin on outflow facility following ciliary muscle retrodisplacement in the cynomolgus monkey.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.