Linked Life Data

7151437

Source:http://linkedlifedata.com/resource/pubmed/id/7151437

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-3-11
pubmed:abstractText
The hierarchy of strength of evidence concerning treatment efficacy ranges from individual anecdotal case reports, through studies with nonrandomized controls, to randomized clinical trials. The importance of randomized trials is their ability to convince the medical community. With randomization, bias (whether conscious or unconscious) is avoided, prognostic factors (both known and unknown) tend to be balanced across treatment groups, the validity of statistical tests of significance is guaranteed, and problems with time trends are avoided. A study of thyroid carcinoma demonstrates the importance of prognostic factors, and indicates how they can be identified using a Weibull model and used to form a prognostic index. A study of prostatic cancer illustrates how covariate information can be used to select optimal treatment for different patient subgroups in situations where there is no single best overall treatment. The key to successful clinical trials is a renewed effort in developing and selecting the treatments to be studied.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0197-2456
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-98
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Patient heterogeneity and the need for randomized clinical trials.
pubmed:publicationType
Journal Article