Linked Life Data

7151034

Source:http://linkedlifedata.com/resource/pubmed/id/7151034

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-3-11
pubmed:abstractText
The NDDO semiempirical molecular orbital method (Kikuchi, 1977; Kikuchi and Maeda, 1977) was used to characterize the reactivities of methylazoxy-methanol (MAM) and its metabolites with DNA nucleophilic base sites. The physical association of MAM was found to occur at the guanine N7 and 06 atoms, while the ultimate alkylation reaction by MAM was predicted to occur at the guanine N7 atom more easily than at the 06 atom of guanine. These trends were also observed in the results for MAM metabolites, methylazoxy formaldehyde (MAF) and methyloazoxy carboxylic acid (MAA), and can explain the experimentally observed selectivity of MAM alkylation on DNA bases (Matsumoto and Higa, 1966; Schank and Magee, 1967). Although the methyldiazonium ion has the highest reactivity with the guanine N7 atom among the MAM metabolites, it is proposed that MAF is another candidate to react directly with the N7 atom of guanine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-7232
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Reactivity of methylazoxymethanol and its metabolites with nucleophilic centers of DNA bases: a semi-empirical NDDO molecular orbital study.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.