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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-1-27
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pubmed:abstractText |
1. The accumulation of [3H]methyltriphenylphosphonium by isolated fat-cells was used to estimate the membrane potential of mitochondria in situ. 2. Adrenaline caused a large decrease in the accumulation of [3H]methyltriphenylphosphonium. Mitochondria in fat-cells incubated in the presence of adrenaline had a very low calculated membrane potential. This effect was also given by isoprenaline (a beta-adrenergic agonist) and was blocked by propranolol (a beta-adrenergic antagonist). 3. The effect of isoprenaline could be partially antagonized by the use of media with high albumin concentrations. Addition of sodium oleate to saturate the fatty acid-binding sites on the albumin reversed this antagonism. 4. It is proposed that the decrease in the calculated mitochondrial membrane potential is due to the uncoupling effect of the non-esterified fatty acids released by the stimulation of lipolysis observed in the presence of beta-adrenergic agonists.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-13866621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-13946593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-13970318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-14169133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-14200124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-18347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-201830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-36613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-383147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4144270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4285775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4285845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4299100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4308837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4315137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4315138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4315935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4324309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4393782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-444499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4452361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-4659260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-5360721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-5648434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-5897912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-6128974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-6274693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-6779011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-6785087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-6987089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-6990973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-7005221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-7030323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-7305896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-7354039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-7370008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7150265-964256
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
206
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
611-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7150265-Adipose Tissue,
pubmed-meshheading:7150265-Animals,
pubmed-meshheading:7150265-Epinephrine,
pubmed-meshheading:7150265-Intracellular Membranes,
pubmed-meshheading:7150265-Isoproterenol,
pubmed-meshheading:7150265-Membrane Potentials,
pubmed-meshheading:7150265-Mitochondria,
pubmed-meshheading:7150265-Onium Compounds,
pubmed-meshheading:7150265-Propranolol,
pubmed-meshheading:7150265-Rats,
pubmed-meshheading:7150265-Trityl Compounds
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pubmed:year |
1982
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pubmed:articleTitle |
The effect of beta-adrenergic agonists on the membrane potential of fat-cell mitochondria in situ.
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pubmed:publicationType |
Journal Article
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