Linked Life Data

7149909

Source:http://linkedlifedata.com/resource/pubmed/id/7149909

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-1-19
pubmed:abstractText
Following monotherapy with cyclophosphamide rat leukemia cells (L 5222) survive only in the CNS, as has been described previously. Here we report on investigations performed to elucidate the influence of rat brain tissue on cyclophosphamide activity. It was found that the toxicity of cyclophosphamide is enhanced 5 fold after incubation with freshly prepared brain homogenate. In parallel experiments it was also found that cyclophosphamide preincubated with brain homogenates is therapeutically less effective toward L 5222 cells than cyclophosphamide alone. The incubation of cyclophosphamide with liver homogenate did not result in the same enhancement of cyclophosphamide toxicity nor in the decrease of therapeutic effects. The different influence of the two tissues on cyclophosphamide suggests two different metabolic mechanisms.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-911X
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
355-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Enhancement of the toxic effect of endoxan after pretreatment with brain homogenates in rats].
pubmed:publicationType
Journal Article, English Abstract