Linked Life Data

7149442

Source:http://linkedlifedata.com/resource/pubmed/id/7149442

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-1-19
pubmed:abstractText
The effect of dopamine on the ventilatory response to transient asphyxia was examined to test the hypothesis that dopaminergic mechanisms modulate carotid body function in humans and to determine whether a change in ventilatory responsiveness is effected by changes in tidal volume or breathing frequency. Five healthy adults were subjected to brief episodes of hypercapnic hypoxia before and at the end of a 45-min intravenous infusion of dopamine hydrochloride (5 micrograms/kg/min). Mean ventilatory response to hypercapnic hypoxia decreased from 1.71 +/- 0.33 L/min/% SaO2 (+/- SD) to 1.30 +/- 0.28 L/min/% SaO2 (p less than 0.05) during dopamine infusion. The fall in ventilatory response was due to a fall in the frequency of breathing (p less than 0.01). Dopamine infusion also produced a small decrease in resting minute ventilation (p less than 0.05) and a small increase in resting end-tidal PCO2 (p less than 0.05). No change was noted in the ventilatory response to progressive hypercapnia. These findings suggest that dopamine acts at the carotid body to depress its response to transient hypoxic stimulation and that this effect is to selectively slow the rate of breathing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
783-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Ventilatory responsiveness to hypercapnic hypoxia during dopamine infusion in humans.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't