rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1983-1-7
|
pubmed:abstractText |
The effect of the chronic cutaneous application of iodine-containing substances on the thyroid function was studied in the guinea-pig. Six iodinated products were daily applied at the rate of 2 g/kg/day for 90 days. We find a quasi-abolition in the thyroid 131I-uptake (reflecting the transcutaneous absorption of free iodine) and an important transient thyroidal hyperproduction during the first month. Then, this primary hyperthyroidism induces a strong pituitary negative feed-back so that the levels of the circulating hormones T3 and T4 are normalized at the end of the experiment; a new hormonal balance is reached with a TSH level reduced by half compared to its normal value.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0174-3015
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
176
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
277-90
|
pubmed:dateRevised |
2009-6-8
|
pubmed:meshHeading |
pubmed-meshheading:7148202-Animals,
pubmed-meshheading:7148202-Anti-Infective Agents, Local,
pubmed-meshheading:7148202-Female,
pubmed-meshheading:7148202-Guinea Pigs,
pubmed-meshheading:7148202-Iodine,
pubmed-meshheading:7148202-Iodine Radioisotopes,
pubmed-meshheading:7148202-Pituitary Gland,
pubmed-meshheading:7148202-Thyroid Gland,
pubmed-meshheading:7148202-Thyrotropin,
pubmed-meshheading:7148202-Thyroxine,
pubmed-meshheading:7148202-Triiodothyronine,
pubmed-meshheading:7148202-Triiodothyronine, Reverse
|
pubmed:year |
1982
|
pubmed:articleTitle |
Consequences of the chronic cutaneous application of iodinated antiseptics on the thyroid function in the guinea-pig.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|