Linked Life Data

7139622

Source:http://linkedlifedata.com/resource/pubmed/id/7139622

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1983-1-19
pubmed:abstractText
We have been investigating possible effects of sex hormones on the carcinogenesis of stomach cancer in Wistar rats that were given N-methyl-N'-nitro-N-nitrosoguanidine in drinking water (50 micrograms/ml) for 4 months. The incidences of stomach cancer in intact male, intact female, castrated male, and castrated female rats at Month 4 of the experiment were 5, 0, 0, and 0% respectively; and those at Month 8 were 40, 10, 0, and 0% respectively; indicating that the incidence in intact males was much higher than in the other groups. The difference in the incidence became more evident when the animals were sacrificed at Month 12 of the experiment (81, 0, 29, and 5%, respectively). Hypertrophy and dissociation of the lamina muscularis mucosae which are considered to occur in the carcinogenic process were observed only in the male rats at the earlier months, but not in female nor in castrated rats. In N-methyl-N'-nitro-N-nitrosoguanidine carcinogenesis, female and castrated rats had a lower incidence of gastric cancers with less change in the lamina muscularis mucosae than did the nontreated male rats. These findings, therefore, suggest that, in addition to the suppressive action of female hormones, male hormones facilitate carcinogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5181-2
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of sex hormones on carcinogenesis in the stomachs of rats.
pubmed:publicationType
Journal Article