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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1983-1-7
|
| pubmed:abstractText |
Buccal uptake, partition characteristics, ionization constants, and urinary excretion were studied for zipeprol and two of its metabolites. Buccal uptake, measured in a single subject, was found to be correlated with n-heptane/water (ph 7.4) partition values of the compounds, and with proportional excretion of the unchanged drug. The importance of the shape of buccal uptake-pH curves in the prediction of absorption and excretion of these compounds is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0142-2782
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
203-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7139061-Cheek,
pubmed-meshheading:7139061-Chemistry, Physical,
pubmed-meshheading:7139061-Chromatography, Gas,
pubmed-meshheading:7139061-Dealkylation,
pubmed-meshheading:7139061-Humans,
pubmed-meshheading:7139061-Hydrogen-Ion Concentration,
pubmed-meshheading:7139061-Mouth Mucosa,
pubmed-meshheading:7139061-Physicochemical Phenomena,
pubmed-meshheading:7139061-Piperazines,
pubmed-meshheading:7139061-Spectrophotometry, Infrared
|
| pubmed:articleTitle |
Buccal uptake, urinary excretion, and physicochemical properties of zipeprol and its N-dealkylated products.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|