Linked Life Data

7139017

Source:http://linkedlifedata.com/resource/pubmed/id/7139017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-1-19
pubmed:abstractText
Differences in the metabolism of testicular and cauda epididymal sperm have been demonstrated for several species, but the region(s) of the ram epididymis in which changes in metabolism occur is not known. In these experiments respirometric and radioisotopic methods were used to monitor metabolic activity of ram sperm isolated from six regions of the epididymis. Effects of exogenous carnitine on metabolism of the sperm also were studied. Sperm from the caput and corpus epididymidis had similar rates of glucose and oxygen consumption and of lactate and CO2 production. However, the magnitude of each parameter was severalfold higher for cauda sperm. In addition, cauda sperm produced 25 times more acetate than caput or corpus sperm. The amount of energy derived from utilization of endogenous substrates was similar for sperm from all regions of the epididymis. Exogenous D,L-carnitine (5 mM) had no effect on the metabolism of caput or corpus sperm. However, when cauda sperm were incubated with carnitine, they consumed less glucose and produced less lactate and more acetate; thus they produced the same amount of ATP from less glucose than did control aliquots incubated without exogenous carnitine. Since the rate of ATP synthesis was equivalent for both incubations, we believe this change in metabolism reflects an increased efficiency of glucose utilization. This increased efficiency may be vital for sperm motility.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-43
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Changes in metabolism of ram sperm associated with epididymal transit or induced by exogenous carnitine.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.