Linked Life Data

7138675

Source:http://linkedlifedata.com/resource/pubmed/id/7138675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1983-1-7
pubmed:abstractText
Cyclophosphamide (CP), a widely used antineoplastic drug, requires hepatic mixed-function-oxidase-mediated activation to show alkylating activity as well as cytotoxicity, oncogenic transformation and chromosomal aberrations. Evidences are here reported that in vivo activation of CP to urinary mutagenic metabolites is catalyzed primarily by a phenobarbital-inducible cytochrome P-450 system. 24 hours urines from male Sprague-Dawley rats treated i.p. by a single CP administration were filtered through XAD-2 columns and mutagenicity of the acetonic extract was assayed by the Ames test in absence of enzymatic microsomal activation. a highly positive response with a linear dose-dependence was obtained in the range 0.500 mg/kg of CP. Treating rats with Phenobarbital, before CP (500 mg/kg) administration, induced a 250% increase in urine mutagenic activity, whereas. -Naphthoflavone pretreatment reduced the CP activation to urine mutagenic metabolites to 51% as compared with control CP-treated rats.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0037-8771
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1061-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[In vivo studies on the transformation of cyclophosphamide to mutagenic metabolites].
pubmed:publicationType
Journal Article, English Abstract