Linked Life Data

7136437

Source:http://linkedlifedata.com/resource/pubmed/id/7136437

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-12-18
pubmed:abstractText
Post-traumatic pulmonary insufficiency or "respiratory distress syndrome" (RDS) is one of the most feared complications of severe trauma. The aetiology is probably multifactorial, and is obscure. Although modern treatment has reduced the mortality, there is no certain way of preventing the syndrome. The aim of the investigation was to develop an experimental model on anaesthetized pigs subjected to trauma and folllowed up for 3-4 days, still under anaesthesia, the repeated lung X-rays and post-mortem naked-eye and histological examination of lung tissue. 26 pigs were used. 12 (Group I) were subjected to missile trauma of a limb, with a fracture that was left without immobilization. 10 were treated similarly but with immobilization of the fracture (Group II). Four control animals were prepared and observed under anaesthesia but no trauma was inflicted (Group III). In Group I, all but two developed, 10-70 h after the injury, roentgen and morphological changes identical to those seen in patients with clinically documented RDS. No such changes were seen in the controls or in Group II. With our experimental model it seems possible to induce in experimental animals roentgen and morphological changes corresponding to RDS in man. The method provides new means of studying the mechanisms behind and the effects of different forms of treatment in RDS. The results also support the hypothesis that early immobilization of fractures is an important step in preventing RDS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0001-5482
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-38
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Primary fracture immobilization as a method to prevent post-traumatic pulmonary changes- an experimental model.
pubmed:publicationType
Journal Article