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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7-8
|
| pubmed:dateCreated |
1982-12-16
|
| pubmed:abstractText |
The sarcoplasmic reticulum in situ is an intricate tubular network that surrounds the contractile material in striated muscle cells. Its topographical relationship to other intracellular components, especially the myofibrils, is rather rigidly maintained by a cytoskeleton which enmeshes Z line material and sarcoplasmic reticulum and, ultimately, is anchored at the plasmalemma. As a result, the two main components of the sarcoplasmic reticulum, the junctional SR and the free SR, retain their typical location in the A band region and in the I band region, respectively. The junctional SR, which is thought to be the site for calcium storage and release for contraction, is, thus, always well within one micron of the regulatory proteins associated with the actin filaments. The junctional SR, a synonym for terminal cisterna applying to both skeletal and cardiac muscle, is generally held to be involved in the translation of the action potential into calcium release, mainly because of the close topographic apposition between the junctional SR and the plasmalemma, especially in skeletal muscle. This attractive structure-function correlation is challenged by the observation that in bird cardiac muscle 80% of the junctional SR is spacially far removed from plasmalemma, the site of electrical activity. This anomalous topography is not in conflict with the notion that translation of the action potential into calcium release may be accomplished by a differential transmitter substance, e.g. calcium. Any hypothesis dealing with this problem must account for the anatomy of the bird heart.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0341-0382
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
665-78
|
| pubmed:dateRevised |
2009-6-8
|
| pubmed:meshHeading |
pubmed-meshheading:7136180-Animals,
pubmed-meshheading:7136180-Birds,
pubmed-meshheading:7136180-Heart,
pubmed-meshheading:7136180-Muscle Contraction,
pubmed-meshheading:7136180-Muscles,
pubmed-meshheading:7136180-Myocardium,
pubmed-meshheading:7136180-Opossums,
pubmed-meshheading:7136180-Sarcoplasmic Reticulum
|
| pubmed:articleTitle |
The anatomy of the sarcoplasmic reticulum in vertebrate skeletal muscle: its implications for excitation contraction coupling.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|