Linked Life Data

7135925

Source:http://linkedlifedata.com/resource/pubmed/id/7135925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-12-18
pubmed:abstractText
The pattern of redistribution of human virulence in epidemic strains of influenza viruses in recombination with human avirulent strains was studied. In the course of recombination of epidemic and attenuated influenza virus strains variants with different human virulence were obtained. Some recombinants manifested enforced reactogenic properties as compared with the epidemic strain (X/28, M/35, and 0/26--H1N1, and 2P--H3N2). At the same time, recombinants No 19 (H1N1) and 1P (H3N2) with a similar set of surface antigens were innocuous for man after intranasal administration. Using the observed differences in sensitivity to remantadine as a marker of recombination, we obtained several sets of recombinants which had the antigenic structure of surface proteins of epidemic viruses and remantadine sensitivity of the other parent.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0507-4088
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
449-52
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
[Variability of the virulent properties of influenza A viruses in recombination].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract