Linked Life Data

7131940

Source:http://linkedlifedata.com/resource/pubmed/id/7131940

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-12-16
pubmed:abstractText
The cardiovascular responses to intravenous doses of epinephrine were assessed in sham-operated, substantia nigra (SN)-lesioned, and SN-stimulated rats under urethane anesthesia. Activation of nigrostriatal dopamine pathways with SN stimulation, although showing no alteration in the epinephrine-induced hypertension, did produce a significant enhancement in reflex bradycardia compared to the controls. In contrast, inhibiting nigrostriatal dopamine pathways with SN lesions led to a significant reduction in the epinephrine-induced bradycardia. Furthermore, local injection of a dopamine receptor agonist apomorphine into the caudate-putamen complex (CP) facilitated reflex bradycardia, while intra-CP injection of dopamine antagonists such as haloperidol and pimozide inhibited it. Moreover, the enhancement in the reflex bradycardia induced by intra-CP administration of apomorphine could readily be abolished by pretreatment with intra-CP administration of either haloperidol or pimozide. Therefore, the present data indicate that a dopaminergic synapse occurs within the caudate-putamen complex which mediates reflex bradycardia in the rat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-521X
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-42
pubmed:dateRevised
2007-3-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Activation of dopaminergic receptors within the caudate-putamen complex facilitates reflex bradycardia in the rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't