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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1982-12-21
|
| pubmed:abstractText |
The title compound was prepared to complete a series of small ring (cyclopropane, cyclobutane) cis/trans 1,2-disubstituted semirigid congeners of acetylcholine. A multistep synthetic sequence, beginning with cis-cyclobutane-1,2-dicarboxylic anhydride, permitted unequivocal preparation of the (+/-)-cis target compound 4. The geometry of 4 was confirmed by comparison with an authentic sample of the (+/-)-trans isomer. The cis and trans isomers were equipotent as muscarinic agonists, but they were much weaker than acetyl-beta-methylcholine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1091-4
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7131487-Acetylcholine,
pubmed-meshheading:7131487-Animals,
pubmed-meshheading:7131487-Chemical Phenomena,
pubmed-meshheading:7131487-Chemistry,
pubmed-meshheading:7131487-Cyclobutanes,
pubmed-meshheading:7131487-Guinea Pigs,
pubmed-meshheading:7131487-Isomerism,
pubmed-meshheading:7131487-Muscle, Smooth,
pubmed-meshheading:7131487-Muscle Contraction,
pubmed-meshheading:7131487-Receptors, Muscarinic
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
(+/-)-cis-2-acetoxycyclobutyltrimethylammonium iodide: a semirigid analogue of acetylcholine.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|