Linked Life Data

7130450

Source:http://linkedlifedata.com/resource/pubmed/id/7130450

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-12-16
pubmed:abstractText
The early postnatal development of neurons, dendrites and synaptic connectivity in kitten substantia nigra (SN) was studied by light and electron microscopy. The compact and reticular divisions of the SN are present at birth but boundaries are indistinct. Most nigral neurons stain deeply in routine histological sections and their diameters increase slightly with age. Ultrastructurally, cell bodies are characterized by eccentrically located and often invaginated nuclei surrounded by cytoplasm rich in well-formed organelles. Axosomatic synapses are infrequent and cell surfaces are enveloped by glial processes. Immature dendritic features, including growth cones and filiform processes, are commonly observed during the first 10 days. Gradually the dendritic profiles elongate and thicken and contours become smoother, retaining only scattered spinelike appendages. Clear examples of the three synaptic types described in cat are found in newborn kittens, but immature terminals contain fewer synaptic vesicles and mitochondria. Approximately 90% of synapses present at birth in both nigra subdivisions are Type I, which contain large pleomorphic vesicles and contact dendrites symmetrically. Asymmetrical contacts characterize most of the remaining definable synapses. The postnatal increase in synaptic connectivity, which was estimated from random photographs of pars reticulata neuropil, is twofold during the first 50 days of life. Initially young dendrites are enveloped by glia and then gradually become ensheathed by axon terminals. Synaptogenesis in pars reticulata reflects the postnatal increase of neostriatal inputs to this subdivision and can be correlated with functional changes in strionigral connectivity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
209
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-38
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The postnatal development of the substantia nigra: a light and electron microscopy study.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.