Linked Life Data

7127147

Source:http://linkedlifedata.com/resource/pubmed/id/7127147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-12-18
pubmed:abstractText
Cellular respiration in vitro was studied in cerebral cortical tissue from rats 2-60 days of age. Respiration was measured polarographically over the temperature range 34-44 degrees C in tissue slices in a basal condition; maximally stimulated by an uncoupler of oxidative phosphorylation, dinitrophenol; and inhibited by a blocker of mitochondrial oxidative phosphorylation, oligomycin. Basal respiration at 34 degrees C increased about 80% between 7 and 30 days of age. Oligomycin-insensitive respiration did not change with age. Dinitrophenol-stimulated respiration was unchanged from 2 to 10 days and then increased over 100% between 10 and 15 days of age. The Q10 for dinitrophenol-stimulated respiration increased from a value of 1 in tissue from rats 2-10 days of age to about 2 in tissue from rats 15 days and older. Our results confirm the previously reported maturational increases in basal respiration and in respiratory capacity in rat cerebral cortical tissue. The maturational increase in maximal respiratory capacity occurs in a short age interval coincident with a marked increase in the Q10 for the hyperthermic temperature range. Both these properties may be important in the increasing resistance to hyperthermia-induced seizures and their functional sequelae in the rat pup.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
In vitro cellular respiration at elevated temperatures in developing rat cerebral cortex.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't