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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 2
|
| pubmed:dateCreated |
1982-12-3
|
| pubmed:abstractText |
The candidacy for streptokinase (SK) infusion was studied in 95 patients displaying ECG evidence of acute or impending infarction who were catheterized within 5 hours of the onset of chest pain. Intracoronary SK was administered to 84 patients in whom occlusions of the infarct-related vessel were identified, with early recanalization having been achieved in 74 (88%). Because of completeness of studies, a data base of 72 patients was employed for further analysis. Recanalization was sustained at follow-up in 45 of 55 patients (82%). Spontaneous thrombolysis was demonstrated at follow-up in five patients (8%) initially resistant to SK, and rethrombosis occurred in 10 patients (18%). Preservation of R waves relative to Q wave depth was limited to patients with less than 90% residual stenosis. Eight of nine patients with continuing thrombolysis and patients with recanalized occlusions of the left anterior descending coronary artery displayed more impressive increases in mean (+/- SEM) ejection fraction (47% +/- 4% to 53% +/- 5% [p less than 0.05], and 47% +/- 3% to 52% +/- 5, respectively). The ejection fraction also increased significantly in 15 patients with pre-SK values of less than 50% (41% +/- 2% to 48% +/- 3%; p less than 0.05). Ventricular function deteriorated in SK failures. Reperfusion arrhythmias occurred in 28 of 62 recanalized patients (45%). Minor bleeding tendencies were displayed in 18 of 72 patients (25%). Major hemorrhages, one of which may have been fatal, occurred in four patients (5.6%). Of 84 patients, four (4.7%) died, two of whom were in cardiogenic shock when first seen. In contrast, there were 11 deaths (11.8%) in a consecutive simultaneously enrolled series of 93 control patients with similar entry criteria (p less than 0.05). Two additional SK-treated patients died, 16 and 30 days after treatment, both more than a week after surgical revascularization. It is concluded that SK recanalization is a promising new therapy that may decrease mortality and preserve myocardial function in certain circumstances. Its efficacy in a setting closer to the mainstream of cardiologic practice extends the favorable experience issuing from earlier clinical investigations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
925-38
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7124613-Adult,
pubmed-meshheading:7124613-Aged,
pubmed-meshheading:7124613-Arterial Occlusive Diseases,
pubmed-meshheading:7124613-Constriction, Pathologic,
pubmed-meshheading:7124613-Coronary Circulation,
pubmed-meshheading:7124613-Creatine Kinase,
pubmed-meshheading:7124613-Electrocardiography,
pubmed-meshheading:7124613-Female,
pubmed-meshheading:7124613-Follow-Up Studies,
pubmed-meshheading:7124613-Humans,
pubmed-meshheading:7124613-Injections, Intra-Arterial,
pubmed-meshheading:7124613-Male,
pubmed-meshheading:7124613-Middle Aged,
pubmed-meshheading:7124613-Myocardial Infarction,
pubmed-meshheading:7124613-Outcome and Process Assessment (Health Care),
pubmed-meshheading:7124613-Physical Exertion,
pubmed-meshheading:7124613-Streptokinase,
pubmed-meshheading:7124613-Stroke Volume
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Intracoronary streptokinase in clinical practice.
|
| pubmed:publicationType |
Journal Article
|