Linked Life Data

7122633

Source:http://linkedlifedata.com/resource/pubmed/id/7122633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1982-12-2
pubmed:abstractText
The Gaucher cell results from the accumulation of excessive glucocerebroside in cells of the monocyte-macrophage system. It is characterized ultrastructurally by the presence of cytoplasmic inclusions which consist of tubule-like structures measuring 130 to 150 Ao in diameter. Utilizing freeze fracture and x-ray diffraction techniques these structures appear to be bilayers measuring 6 nm in thickness, 40 to 60 nm wide and up to 600 nm in length. The Gaucher cell contains isoenzyme 5 of acid phosphatase which is resistant to prior incubation in tartaric acid. The bone marrow smears from patients with Gaucher's disease contain monocytes and monocytoid cells which contain inclusions which are acid phosphatase positive and resemble the acid phosphatase positive inclusions in the Gaucher cells. Ultrastructural studies of monocytes from Gaucher patients demonstrated membrane-bound inclusions containing tubule-like structures identical to those in Gaucher cells. These monocytic cells appear to represent precursors of Gaucher cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Pathology of the Gaucher cell.
pubmed:publicationType
Journal Article