Linked Life Data

7121721

Source:http://linkedlifedata.com/resource/pubmed/id/7121721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-12-2
pubmed:abstractText
Synaptosomal acetylcholine synthesis was found to be dependent on the presence of Na+-dependent HC-3 sensitive choline transport at low (5.5 mM) and high (35 mM) K+ concentrations. However, at 5, 20, and 100 microM choline, choline phosphorylation was proportional to total choline uptake, in the presence or absence or high affinity transport. Only in the presence of eserine (50 microM) did acetylcholine synthesis increase as the choline concentration was elevated from 20 microM to 100 microM, and this effect was observed at low and high K+ concentrations. Our results suggest that: 1) the synthesis of non-surplus synaptosomal ACh is dependent on high affinity choline transport; and 2) choline is equally likely to be phosphorylated after being taken up by low or high affinity transport.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0364-3190
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
749-59
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Acetylation and phosphorylation of choline following high or low affinity uptake by rat cortical synaptosomes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.