Linked Life Data

712072

Source:http://linkedlifedata.com/resource/pubmed/id/712072

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1979-1-15
pubmed:abstractText
Complete or partial protection against the line-10 hepatocarcinoma was conferred to a significant number of strain-2 guinea pigs by the passive transfer of antibodies reactive to antigens from line-10 cells. Immunoglobulins were administered intradermally and injected sites were subsequently challenged with line-10 cells. Immunoglobulins prepared from the sera of rabbits that had been immunized to line-10 cells and from the sera of guinea pigs that had been rendered immune to this tumor by previously described methods were more effective than immunoglobulins obtained from normal rabbit or guinea pig sera. Protection was abolished if immunoglobulins were absorbed with line-10 cells. Antitumor effects were dependent on the close contact of antibodies and tumor cells. Protection was greater if normal syngeneic peritoneal exudate cells were transferred in addition to the immunoglobulins. A possible mechanism for the antitumor effects observed is that of antibody-dependent cellular cytotoxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1933-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Suppression of growth of guinea pig line-10 hepatocarcinoma. II. Effect of passive transfer of xenogeneic and syngeneic antibodies and normal lymphoid cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.