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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1982-12-2
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pubmed:abstractText |
A GC method using dual nitrogen selective and flame ionization detectors was developed for the determination of N-nitrosodesipramine using N-butyryldesipramine as the internal standard. The precision of the method was found to be +/- 5.0% and the accuracy was +/- 4.9%. The method could be used to detect 10 ng/ml of N-nitrosodesipramine in bacterial cultures. When desipramine and sodium nitrite were incubated with aerobic or anaerobic bacteria, the nitrosamine level was found to be 10-300 times higher than the controls. When imipramine and potassium nitrate were incubated with a mixed anaerobic culture, the level of N-nitrosodesipramine was found to be 4.5 times higher than the control.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
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pubmed:issn |
0022-3549
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
901-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7120093-Aerobiosis,
pubmed-meshheading:7120093-Anaerobiosis,
pubmed-meshheading:7120093-Animals,
pubmed-meshheading:7120093-Bacteria,
pubmed-meshheading:7120093-Biotransformation,
pubmed-meshheading:7120093-Chromatography, Gas,
pubmed-meshheading:7120093-Desipramine,
pubmed-meshheading:7120093-Imipramine,
pubmed-meshheading:7120093-Intestines,
pubmed-meshheading:7120093-Male,
pubmed-meshheading:7120093-Rats,
pubmed-meshheading:7120093-Rats, Inbred Strains
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pubmed:year |
1982
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pubmed:articleTitle |
Study of the metabolic conversion of imipramine and desipramine to N-nitrosodesipramine by bacteria using a nitrogen-selective GC analysis.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|