Linked Life Data

7119876

Source:http://linkedlifedata.com/resource/pubmed/id/7119876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1982-12-3
pubmed:abstractText
Oligodendrocyte formation and myelination in the optic nerve of rats treated with cortisol on postnatal days 7 and 18 were investigated at 21 and 60 days by autoradiographic and morphometric methods. At 21 days, the amount of myelin in the optic nerve of treated rats was reduced by 42%. This reduction was accompanied by a 39% decrease in the number of myelinated axons. In addition, the myelin/axon area ratio was reduced 22% for those axons which were myelinated. At 60 days, the amount of myelin, the number of axons myelinated, the average axonal size, and the average amount of myelin per axon had completely recovered to normal values. Tritiated thymidine-labeling experiments showed that the genesis of oligodendrocytes was enhanced following the cessation of treatment. Since the number of oligodendrocytes in the optic nerve of treated rats was normal at 60 days, it is suggested that the retarding effect of cortisol on myelination in the optic nerve may be mediated, at least in part, by inhibited formation of oligodendrocytes during treatment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1292-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Recovery of myelination in rat optic nerve after developmental retardation by cortisol.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.