| pubmed-article:7118914 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C0014653 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C0002270 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7118914 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7118914 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:7118914 | pubmed:dateCreated | 1982-12-3 | lld:pubmed |
| pubmed-article:7118914 | pubmed:abstractText | The relative translational efficiency of the two human alpha-globin mRNAs, alpha 1 and alpha 2, was measured in vitro in a rabbit reticulocyte lysate system. To differentiate the translational products of these two mRNAs which normally encode an identical alpha-globin protein product, we used reticulocyte mRNA from a recently described Chinese subject. In this subject, an electrophoretically distinct alpha-globin mutant is encoded at the alpha 2 locus and both the alpha 1- and alpha 2-globin genes are deleted from the homologous chromosome (--/alpha 125Pro alpha). As in normal controls, the concentration of alpha 2-globin mRNA exceeded alpha 1 by approximately 3-fold. However, alpha 1- and alpha 2-globin proteins were synthesized by this reticulocyte mRNA at equal rates. This data suggests that the equal expression of the two alpha-globin genes observed in human erythrocytes results from a balance between the 3-fold excess of alpha 2-globin mRNA and a 3-fold higher translational efficiency of alpha 1-globin mRNA. The disparate translational efficiencies of the two alpha-globin mRNAs may be determined by the divergent structure of their 3' noncoding regions. | lld:pubmed |
| pubmed-article:7118914 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7118914 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7118914 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7118914 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7118914 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7118914 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7118914 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7118914 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7118914 | pubmed:author | pubmed-author:KanY WYW | lld:pubmed |
| pubmed-article:7118914 | pubmed:author | pubmed-author:LiebhaberS... | lld:pubmed |
| pubmed-article:7118914 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7118914 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:7118914 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:7118914 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7118914 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7118914 | pubmed:pagination | 11852-5 | lld:pubmed |
| pubmed-article:7118914 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:meshHeading | pubmed-meshheading:7118914-... | lld:pubmed |
| pubmed-article:7118914 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:7118914 | pubmed:articleTitle | Different rates of mRNA translation balance the expression of the two human alpha-globin loci. | lld:pubmed |
| pubmed-article:7118914 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7118914 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7118914 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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