Linked Life Data

711724

Source:http://linkedlifedata.com/resource/pubmed/id/711724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1979-1-26
pubmed:abstractText
The present study was performed in order to establish if there is any correspondence between specific parameters of tissue reaction to implanted biomedical materials and in vitro cytotoxicity. The presence of various types of inflammatory cells and/or necrosis in rats implanted subcutaneously with a series of 42 alpha-amino acid copolymers and their esters was compared with their in vitro toxic effects, as determined by an agar overlay technique. Only necrosis appeared to correlate with reactions scored as strongly positive by tissue culture procedures. Future studies with slightly toxic materials should assess if tissue culture methods could be helpful in predicting other levels of reaction at the polymer-tissue interface.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0145-3068
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
In vitro cytotoxicity and in vivo acute responses to some amino acid copolymers and their esters.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S.