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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1982-12-3
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pubmed:abstractText |
1. Myofibrillar protein breakdown was calculated from the urinary excretion ratio of NT- methylhistidine (3-methylhistidine) to creatinine in newborn premature and full-term infants. Representative values were obtained from single voidings provided that the infant's metabolic status was stable. 2. NT- Methylhistidine in infant urine was measured by a rapid Auto Analyser method and shown to give similar values to those obtained by ion-exchange separation techniques. 3. The molar excretion ratio of NR- methylhistidine to creatinine averaged 0.0159 in urine samples obtained within 12 h after birth. A similar ratio was found in amniotic fluid collected at birth. It is argued that this ratio does not reflect a low rate of myofibrillar protein breakdown in the foetus, but rather a more effective transplacental passage of NT- methylhistidine than of creatinine. 4. The urinary ratio increased during the first 2 days after birth to a plateau at 0.0372. This represents a myofibrillar protein degradation rate of 3.40% day-1 in full-term infants. 5. The molar excretion ratio during the period 40-120 h after birth increased in premature infants and reflects a fractional degradation rate of 5.34% day-1 in those infants weighting less than 1 kg at birth. 6. Lower excretion ratios were found in some infants of diabetic mothers and in athyroid infants. 7. The urinary excretion ratio of NT-methylhistidine to creatinine is presented as a useful method for evaluating the breakdown rate of myofibrillar protein in neonates and can be applied to a number of abnormal nutritional or hormonal states.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0143-5221
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7116782-Amniotic Fluid,
pubmed-meshheading:7116782-Birth Weight,
pubmed-meshheading:7116782-Creatinine,
pubmed-meshheading:7116782-Female,
pubmed-meshheading:7116782-Humans,
pubmed-meshheading:7116782-Hypothyroidism,
pubmed-meshheading:7116782-Infant,
pubmed-meshheading:7116782-Infant, Newborn,
pubmed-meshheading:7116782-Infant, Newborn, Diseases,
pubmed-meshheading:7116782-Infant, Premature,
pubmed-meshheading:7116782-Methylhistidines,
pubmed-meshheading:7116782-Muscle Proteins,
pubmed-meshheading:7116782-Myofibrils,
pubmed-meshheading:7116782-Pregnancy,
pubmed-meshheading:7116782-Pregnancy in Diabetics
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pubmed:year |
1982
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pubmed:articleTitle |
Measurements of myofibrillar protein breakdown in newborn human infants.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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