Linked Life Data

7116570

Source:http://linkedlifedata.com/resource/pubmed/id/7116570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1982-12-2
pubmed:abstractText
3-Methyladenine is one of the major products formed by reaction of a large number of environmental methylating agents with DNA in vivo and in vitro. In spite of the rapid spontaneous depurination of this base an enzyme, 3-methyladenine DNA glycosylase, has been shown to catalyse its excision. The relevance of this enzyme in carcinogenesis induced by alkylating agents was studied. Acute or chronic treatment of rats with diethylnitrosamine or with N-acetylaminofluorene caused a slight increase in glycosylase activity in liver. Experiments with liver regenerating after partial hepatectomy showed a similar increase to occur at the time of DNA replication. It could be that the increase found after treatment with carcinogens was related to the accompanying increase in cell replication, rather than being the result of a specific induction by the carcinogen. Glycosylase activity was found to be higher in the liver of the rabbit and cat than in rat or hamster liver. Organ differences (liver, kidney and brain of the rabbit) were smaller than the species differences found for enzyme activity in liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
747-50
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The activity of 3-methyladenine DNA glycosylate in animal tissues in relation to carcinogenesis.
pubmed:publicationType
Journal Article