Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-10-29
pubmed:abstractText
Purified rat tumour Leydig cells were pretreated with or without lutropin (1 h at 32 degrees C). The plasma membranes were then isolated and the adenylate cyclase activity measured in the presence of freshly prepared or heat-inactivated (1 h at 60 degrees C) human erythrocyte membranes. In plasma membranes from control cells in the presence of heat-inactivated human erythrocyte membranes both guanosine 5'-[beta, gamma-imido]triphosphate (p[NH]ppG) plus lutropin and NaF caused a 45--50-fold increase in cyclic AMP production over 30 min compared with 12--13 fold p[NH[ppG and 2--3-fold with lutropin alone. In plasma membranes isolated from lutropin-pretreated cells the NaF- and the p[NH]ppG-stimulated cyclic AMP production rates were unchanged, but no effect of lutropin could be demonstrated with or without added p[NH]ppG. However, after mixing lutropin-desensitized Leydig tumour-cell plasma membranes with freshly prepared human erythrocyte plasma membranes, the adenylate cyclase activity in the presence of lutropin, p[NH]ppG, lutropin plus p[NH]ppG and NaF were similar to those of control cell plasma membranes treated in the same manner. The possible mechanisms of this reversal of lutropin-induced desensitization by human erythrocytes are discussed.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-177461, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-221192, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-4278921, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-4334491, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-6105841, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-6243282, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-6245715, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-6274319, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-6284136, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-6932020, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-7016117, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-7325977, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-7462233, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-885870, http://linkedlifedata.com/resource/pubmed/commentcorrection/7115353-98070
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
204
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Resensitization of lutropin-desensitized tumour Leydig-cell adenylate cyclase with human erythrocyte membranes.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't