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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1982-10-29
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pubmed:abstractText |
Although the reflex cardiovascular and ventilatory responses evoked by stimulation of groups III and IV muscle afferents have been extensively investigated, less is known about the effects of stimulation of these afferents on airway caliber. Therefore, in 11 chloralose-anesthetized dogs, we recorded transverse smooth muscle tension from an innervated segment of the trachea, while we stimulated groups III and IV muscle afferents with capsaicin and bradykinin. Injection of both substances into the arterial supply of the skinned hindlimb evoked dose-dependent decreases in tracheal tension, whereas injection into the femoral vein either increased tension or had no effect on it. Injection of capsaicin and bradykinin into the arterial supply of the gracilis muscle also decreased tracheal tension. In addition, cutting the sciatic, gracilis, and femoral nerves abolished the decreases in tracheal tension caused by injection of capsaicin and bradykinin into the arterial supply of the hindlimb. We conclude that chemical stimulation of groups III and IV muscle afferents causes reflux relaxation of tracheal smooth muscle in dogs.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
243
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R383-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7114294-Animals,
pubmed-meshheading:7114294-Blood Pressure,
pubmed-meshheading:7114294-Bradykinin,
pubmed-meshheading:7114294-Capsaicin,
pubmed-meshheading:7114294-Dogs,
pubmed-meshheading:7114294-Heart Rate,
pubmed-meshheading:7114294-Muscle, Smooth,
pubmed-meshheading:7114294-Muscle Contraction,
pubmed-meshheading:7114294-Muscle Relaxation,
pubmed-meshheading:7114294-Neurons, Afferent,
pubmed-meshheading:7114294-Trachea
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pubmed:year |
1982
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pubmed:articleTitle |
Reflex relaxation of tracheal smooth muscle by thin-fiber muscle afferents in dogs.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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