Linked Life Data

7114246

Source:http://linkedlifedata.com/resource/pubmed/id/7114246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-10-29
pubmed:abstractText
The effect of thyrotoxicosis on the capacity of fragmented sarcoplasmic reticulum (FSR) and crude homogenate (CH) to sequester Ca2+ was determined in rat muscle for the slow-twitch type I soleus (SOL), the fast-twitch type IIA deep region of the vastus lateralis (DVL),and the fast-twitch type IIB superficial region of the vastus lateralis (SVL). The maximal rate of Ca2+ uptake (Vmax) and Km were determined in both the CH and FSR preparations, and the total Ca2+ uptake capacity of the CH was determined. In the slow SOL, thyrotoxicosis increased the Vmax (8.20 +/- 0.96 vs. 15.70 +/- 0.92 mumol Ca2+ . g wet muscle-1 . min-1) and the total Ca2+ uptake (17.62 +/- 1.30 vs. 27.13 +/- 2.16 mumol Ca2+ . g wet muscle-1) of the CH preparation. Thyrotoxicosis increased the FSR yield 2.3-fold in the slow-twitch SOL; however, the kinetic characteristics (Vmax and Km) of these vesicles were not altered. Thyrotoxicosis had no effect on the CH and FSR preparations in either the type IIA or type IIB sample. These results can be explained by a thyroid hormone-mediated increase in the quantity of the sarcoplasmic reticulum in type I muscle and suggest no effect on the hormone on the qualitative nature of the Ca2+-enzyme interaction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
243
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
C151-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of thyrotoxicosis on sarcoplasmic reticulum in rat skeletal muscle.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't