Linked Life Data

7110989

Source:http://linkedlifedata.com/resource/pubmed/id/7110989

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
30
pubmed:dateCreated
1982-10-21
pubmed:abstractText
Samples of gastric fluid were tested for pH and number of bacteria in 20 patients who received cimetidine 400 mg prior to selective gastric surgery. The results were compared with those obtained in a group of surgical patients who did not receive the drug. The cimetidine-treated patients had alkaline gastric fluid with pronounced bacterial growth (4.7 +/- 0.6 x 10(4) micro-organisms/ml), whereas 18/20 untreated patients has a sterile gastric fluid. Similar results were observed in 14 intensive care patients treated for 24 hours with cimetidine. The effect proved reversible: 12 hours after treatment was discontinued bacterial growth could only be demonstrated in 3/14 patients. Thus, short-term cimetidine treatment results in a rise of gastric pH with marked bacterial proliferation. This may have serious consequences in cimetidine-treated patients about to undergo gastric surgery or likely to develop aspiration pneumonia.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0301-1518
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2281-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Influence of cimetidine on bacterial growth in gastric fluid (author's transl)].
pubmed:publicationType
Journal Article, English Abstract