Linked Life Data

7110758

Source:http://linkedlifedata.com/resource/pubmed/id/7110758

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-10-12
pubmed:abstractText
The electrophysiologic effects of procainamide in young animals have not been established. To test the effects of this drug on the immature heart, we studied eight nonsedated, chronically instrumented puppies (age range 12-28 days, median 16 days; weight range 0.7-1.1 kg, median 0.8 kg). The electrophysiologic study was performed before and 30 minutes after procainamide was given intravenously (20 mg/kg infusion). At the time of the study, the serum concentrations of procainamide (8.2 +/- 1.7 micrograms/ml to 6.2 +/- 1.6 micrograms/ml; mean +/- SEM) were in the usual adult human therapeutic range (4-10 microgram/ml). Procainamide in puppies caused a significant lengthening of the atrial and ventricular refractory periods, a significant decrease of the sinus node recovery time and the sinus of atrial echo zone, a significant decrease in the heart rate, and a significant increase in the sinoatrial conduction time.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-322X
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-73
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
The electrophysiologic effects of procainamide in the immature heart.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't