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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1982-10-29
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pubmed:abstractText |
To determine whether chronic saline ingestion is required for protection against acute renal failure, we examined the effect of the time at which saline was offered. Water-drinking rats developed severe azotemia (BUN 115 +/- 6 mg/dl; 41 +/- 2 mmol/l) 24 h after 50% glycerol i.m. Chronic saline ingestion for 30 days conferred protection only if continued after the insult (BUN 49 +/- 4 mg/dl; 18 +/- 1 mmol/l; p less than 0.01) but not if saline was withdrawn (BUN 110 +/- 8 mg/dl; 38 +/- 3 mmol/l). Moreover, saline offered only after the insult conferred equivalent protection (BUN 57 +/- 6 mg/dl; 32 +/- 2 mmol/l). Fluid intake, arterial blood pressure and plasma volume were better sustained in saline-drinking rats.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0028-2766
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7110466-Acute Kidney Injury,
pubmed-meshheading:7110466-Animals,
pubmed-meshheading:7110466-Blood Urea Nitrogen,
pubmed-meshheading:7110466-Drinking,
pubmed-meshheading:7110466-Glycerol,
pubmed-meshheading:7110466-Male,
pubmed-meshheading:7110466-Rats,
pubmed-meshheading:7110466-Rats, Inbred Strains,
pubmed-meshheading:7110466-Renin-Angiotensin System,
pubmed-meshheading:7110466-Sodium Chloride
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pubmed:year |
1982
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pubmed:articleTitle |
Saline- and glycerol-induced acute renal failure: 'protection' occurs after insult.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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